Everything you need to know about suppositories by Billee Sharp

The efficient delivery of medication is a crucial step in the healing process, but just taking a dose doesn’t ensure that your body absorbs all the medicine. Often taking medication orally can create digestive problems, sensitivity to medication is common and when medication is taken long-term the gut can lose the capacity to process it effectively. It comes as a  surprise to learn that suppository delivery scores high in terms of of effective dosing without side effects.

It is a common assumption that suppositories are used mainly for localized issues. i.e. laxatives and yeast infection treatments are often prescribed in suppository form. However research into efficient delivery systems show that suppositories allow for direct entry into the bloodstream and this yields greater absorption rates than oral ingestion. This direct bloodstream path is particularly valuable for those taking high doses of THC as the liver is bypassed and THC’s psychoactive component is not metabolized..

Cannabis suppositories are first mentioned circa 3000 BC in Egyptian medicinal texts, recommended for pain relief, menstrual problems, migraines and hemorrhoids. Nowadays cannabis-rich suppositories are recommended for a wider range of health issues which we’ll discuss here. 

There is a decided shortage of research into vaginal suppository use but women are using cannabis vaginally for a variety of reasons. Menstrual cramping can be severely debilitating and women are often advised to take oral contraceptives to reduce pain and blood flow. Many women are turning to cannabis suppositories to relieve menstrual pain, by using 1:1 CBD:THC suppositories, cramping is relieved by reducing local inflammation with CBD and pain relief with THC. Synergy suppositories are made with broad spectrum CBD:THC oil which adds the benefits of the entourage effect of CBG, CBN and other minor cannabinoids.

Abnormal PAP smears indicating abnormal cervical cells can also be treated with 1:1 CBD:THC suppositories, the presence of CBD and THC is known to cause cell apoptosis (destruction) of abnormal cells.

For women, during perimenopause, menopause and postmenopause, systemic hormonal changes create many health issues. The loss of estrogen often manifests in dry skin conditions for the vulva and vagina. This can lead to inflamed vulva, itching and flaking surface skin and thinning of the vaginal walls making intercourse painful.

There is a growing awareness in mainstream womens’ health discourse about cannabis suppositories for enhanced pleasure, restorative value and pain relief. Our member testimonial describes how using 1:1 CBD:THC suppositories alleviated her internal discomfort making intercourse the fun that it should be! Read it here.

Research into the EndoCannabinoid System (ECS) and female reproductive system shows receptors influencing ovarian function and present throughout the sexual organs. The ECS also plays an active role in sexual desire this explain’s the popularity of  cannabis suppositories  as a relaxant and an aphrodisiac both here and in Europe.

For men, suppositories are a rectal proposition and one which allows high doses of medication to be taken without psychoactive effects. Often oral ingestion can cause digestive problems and absorption through the gut can reduce the dosage delivery over time. High cannabis content in suppositories are used for chronic conditions particularly pain management and anti-cancer protocols as a single suppository can deliver up to twenty times more medicine per dose than is possible through oral delivery. Synergy founder, Leonard Leinow, writes about his suppository protocol for treating an aggressive form of prostate cancer here.

High cannabis dosages are recommended for an anti-cancer protocol and may also be needed to treat chronic pain conditions. These high doses would not be tolerable for most people to take orally but suppository delivery bypasses the liver preventing the psychoactive cannabinoid from activation.

Cannabis suppositories are also useful in delivering directly to localized inflammation, relieving hemorrhoids, anal fissures and acting on enlarged prostate conditions. Many other pain issues including sciatica, restless leg syndrome, lower back pain and post-operative pain respond well to suppository delivery.

Despite the many advantages of suppository delivery there is still the hurdle of insertion to overcome! This tends to be an issue for many men and women but ultimately it's an easy maneuver to master! Most people use suppositories at night, laying down reduces the chance of any leakage as the body absorbs the oil.

Suppositories are commonplace in Europe. At Synergy part of our mission is to share information on how to use cannabis medication successfully, we recommend suppositories as a highly effective delivery system with no side effects.

Further Reading:

“The role of of the Endocannabinoid System in Female Reproductive Tissues” https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-018-0478-9

“Do Cannabis Suppositories work?” https://projectcbd.org/health/cannabis-suppositories/

“Circulating Endocannabinoids Concentrations And Sexual Arousal In Women”  https://pubmed.ncbi.nlm.nih.gov/22462722/

Synergy Suppositories Might Well Have Saved my Marriage

What you may not know because no one ever talks about it is that during menopause, many women suffer from vaginal atrophy due to hormonal changes and the associated loss of collagen. That basically means the tissue of the vagina becomes very brittle and the whole canal tends to shrink! Sex can be very painful - as it was for me - and so I started wanting it less and less much to the chagrin of my husband. I started using the THC/CBD suppositories from Synergy on nights when I thought a morning of lovin' would likely follow and they helped soooo much with the atrophy (as well as dryness) that now sex is enjoyable again! I am forever grateful and highly recommend them for this purpose! ~ Elana Dusse

LL Prostate Journey by Leonard Leinow

Leonard’s Prostate Journey:

In October, 2023, during a physical exam at Kaiser, I was informed I had a “nodule” on my prostate, a protruding tumor that is small, less than 1 cm. This one was pushing up on the surface of the prostate wall, such that it can be felt with a finger during a digital exam. I was told it was shaped like a coin, flat and round, and raised with a definite ridge around the edge, very firm and hard. 

I did a biopsy, where they drill 14 holes taking core samples. The lab test results showed that 4 of the samples were positive with cancer in them. The grade of the cancer was quite high. One sample had a Gleason score 8 (4+4), which is considered “Aggressive and High Risk”. Three other samples were Gleason score 7 (4+3), on both sides of the prostate, making it a bilateral condition. 

Gleason 8 with activity on both sides of the prostate, is not good news. However, as an optimist, I noticed the other 10 core samples did not have any cancer in them. Only 4 out of 14 were positive. That is only 28% positive, which means 78% of the test results were healthy normal cells.

Next, we did a PSMA PET scan to assess if there is any spreading or metastasis, a test required before getting a diagnosis and a treatment plan.

It was one month between the biopsy and the PET scan. Until I had the results of the scan, there was nothing I could do. It was interesting to watch the mind wanting to get carried away with OMG scenarios. Diligently watching the mind was like being in a month-long meditation retreat.

Finally, the PET scan confirmed that the cancerous tumor was totally contained within the walls of the prostate. YEAH!!!  No spreading to any lymph nodes or other locations. The tumor has probably been growing for 20 years. Even though they are calling it “aggressive”, it is not growing fast. I also learned 80% of men age 80+ have cancer in their prostate.  Most men die with it, not from it. I’m 81 years old now.

Treatment Options:

Kaiser said I was too old to have a proctectomy, surgical removal, because of probable side effects, like incontinence and erectile disfunction.  The only option Kaiser offered was radiation, coupled with ADT therapy. ADT (androgen deprivation) is hormone therapy to eliminate testosterone.

I wanted a second opinion. At UCSF, I got an appointment with Dr. Peter Carroll, the head of the Urology Department. He is a nationally acclaimed expert in this field. He examined me, ran a bunch more tests and his recommendation was the same: Radiation, plus ADT therapy.

I told him I was reluctant to do either of these. Dr. Carroll agreed to put me on an “Active Surveillance” program. He would monitor me through the process to get scans (PET, MRI, Ultrasound, etc.) every 4-6 months. I also would get quarterly PSA blood tests. So far, my PSA was fairly low, around 4.0.

“This is a slow growing cancer, with a low stage, but a high grade. Because it is in the high risk and aggressive range”, doctors say “the tumor will definitely grow and spread, someday”. I must confess; I am a rebel, A Rebel With a Cause. When given the diagnosis, I listened to what the doctors said. In addition, l  listened deep inside with my intuition. I use my connection with Spirit. When I heard this diagnosis, I could not believe it. My gut said “There must be another Way”. I believe all things are possible. I believe this can be managed. I believe we all have the power to heal ourselves.

My theory, based on observing clients over the years; Cannabis can help manage cancer in a couple of ways:

• A) It can stop the growth of the tumor. High doses of CBD can manage the growth rate of cancer cells. CBD inhibits the propagation of new cancer cells.  This prevents the return of cancer.

• B) It can dissolve the tumor. High doses of THC cause the tumor to dissolve. It encourages apoptosis of the cancer cell. If one can physically feel the tumor, it usually starts off hard like a rock. Then, after some time, it feels softer, like a grape. And then, after some more time, it can’t be found. It disappears.  It’s not really shrinking it, rather, it is dissolving. It may still have the same lineal dimension, but the density is reducing.

• C) We are not stuck using what used to be the only method of consumption. High doses taken orally resulted in extreme high psychoactivity.The cannabinoids taken via a suppository will travel throughout the body via the lymphatic and blood system, bypassing the liver, and are not psychoactive.

In my case, the cancer had not spread beyond the prostate walls at all. NO metastasis. No Cancer is showing up in any lymph nodes. Because of this, I have the luxury of time to look into alternative methods.

I have chosen a Holistic approach to manage my condition, using Diet, Life Style, Meditation, Supplements, Exercise and Cannabis therapy.

• Cannabis Suppositories – I am taking 600 mg of cannabinoids in suppository form every day (200 CBD, 200 THC, 100 CBG, 100 CBN). FYI taking THC as a rectal suppository is not psychoactive, even high doses like this, which is the equivalent of 20 doses orally. Also, suppositories put the cannabinoids right next to the prostate, where they are needed.  (Synergy Wellness #685)

•  Supplements – I am taking lots of vitamins and medicinal mushrooms. I make a juice drink made from fresh turmeric and ginger root with grapefruit.

• Diet – The main core of my diet is zero sugar, because sugar feeds cancer.  This self-designed diet is a Vegan-ish Mediterranean diet with seafood.

• Increased Exercise – 30+ minutes / day – swimming, strength training, biking.

• Heat Therapy – 2-3 long (30 minute) hot (180F) saunas a week.

This was a real wake-up call. I had to look at every aspect of my life. I have reframed this in my mind. Instead of having cancer, I have a Metabolic Disorder, and I am managing it quite well.  Most importantly, I have changed my outlook on life. I am more glad to be alive. I am much more appreciative of every moment, enjoying the beauty of nature and my connection with all life. I have much more gratitude.  My current motto is: Less Stress and More Love.

All of this work is slowly moving the needle in the right direction. After one year, the tumor is stable, not growing. Scans show a slight decrease in prostate size, by 11%.  The nodule, while still there, is not as prominent, not protruding as much, no ridge and the edges are rounded.  One doctor said the tumor felt softer to touch. 

All very good news and I feel great. I want to emphasize that cannabis alone does not cure cancer. However, combining cannabis therapy together with a healthy lifestyle and a healthy diet, will give you a better chance to live in harmony with cancer. The doctors agree I should keep doing whatever I am doing. I figure I have about one more year to go with my current protocol before it disappears altogether. Thank you, Great Spirit. I am definitely full of gratitude and Giving Thanks on this day of Thanksgiving.

With Love,

Leonard

The Wizard of Woodacre 

If you want more details, please send me an email: Leonard@synergyCBD.com